Adaptive Mechanisms of Root System of Rice for Withstanding Osmotic Stress

Being one of the major cereal crops, rice has a great effect on food security of the world population. But worldwide rice production faces severe threat due to a combination of factors like uncontrolled human rise, limited agricultural land and increasing environmental stresses. Coping with this situation is an urgent call for meeting the challenge. For overwhelming rice production by battling with this condition, scientists and researchers try their best to develop such rice varieties which can adapt to adverse climatic conditions. But, the majority of the research efforts are given on above ground parts of rice to make it stress tolerant. Root, one of the major parts of plant, remains unnoticed although it has immense possibility of adaptation under stress conditions. Fruitful and efficient utilization of limited resources are possible through healthier and competent root systems. Selection and breeding of rice genotypes with extensive root systems may contribute to more efficient use of soil nutrient resources and this ultimately influences the yield stability of rice

Drought Affected Wheat Production in Bangladesh and Breeding Strategies for Drought Tolerance

Wheat is one of the major cereal crops in Bangladesh. Over the last two decades, wheat consumption has passionately amplified in Bangladesh but its production has declined due to various stress environments. Recurrent drought event due to climate change that threatens the country’s food safety has become a serious concern. To safeguard the food security, adopting suitable breeding strategies can add momentum. Developing drought tolerant wheat varieties are the definitive means of protecting the crop against hostile effects of drought. Plant breeders are exploring various breeding strategies to breed for the varieties that can cope with water deficient conditions well. Besides, breeders are consistently looking for new prospects and strategies that can boost genetic gain in yield. To endorse drought tolerance in wheat, understanding the physiological and genetic adaptation mechanisms of wheat cultivars during drought stress would provide the estimated benchmarks to adjust for suitable breeding programs. The efforts of developing drought tolerant wheat genotypes could be supported by different breeding strategies including in vitro haploid and double haploid protocols, polyploidization, development of various types of hybrids and induced mutants by utilizing both classical and molecular breeding techniques. The proposed book chapter shall discuss the pattern of drought-stress in the wheat growing regions, effects of drought stress on wheat production and suitable breeding strategies for developing drought tolerant genotypes in Bangladesh

Pre and Present COVID-19 Situation: A Framework of Educational Transformation in South Asia Region

This study is designed to support the development of strategies to recover from the disrupted impact of COVID-19 on HE institutes of the South Asian Region (SAR), as the nations in this region are severely cursed by poverty and unemployment. During the unusual phase of the COVID-19 pandemic, the face-to-face learning method is no longer appropriate, and the crisis leads to force on distance learning instead of physical learning. Like all other educational institutions, HE institutions are also in big trouble. Changes in educational structure change the pattern of academic work, which may have an inverse impact on acquiring knowledge and improving skills. Not only students but also a greater number of teachers at the HE institutions required to continue their service through online during this closure period. However, well digital infrastructure and digital contents appear to be the prime requirements for this educational transmission, which are extensively accessible in SAR countries. By following a mixed-methods strategy, the study specifically examines the impact of the pandemic on higher education in the South Asian Region, with an emphasis on the impact on learners, educators, and institutions, and to identify the measures that have been taken by these countries to survive and continue the education system with all the obstacles of the crisis. It concludes with some vital suggestions that may be applied to mitigate the crisis moment and assist in moving forward with more technological advancements for a new future. Doi: 10.28991/ESJ-2023-SPER-06 Full Text: PD

Red Seaweed Gracilaria Arcuata in Cage Culture Area of Lawas, Sarawak

Red seaweed Gracilaria sp. is known as ‘Janggut Duyong’ by the local people of Sarawak. This macroalgae is well-distributed in both temperate and tropical seawaters. Gracilaria sp. could be processed to produce agar for industrial purposes whereas some people consumed it directly and become part of their daily diet. In terms of ecology, Gracilaria sp. is one of primary producer in the seawater and its presence can form habitats to support other aquatic organisms. Despite its socio-economic and ecological importance, little is known about Gracilaria sp. in Sarawak. Hence, this study is designed to: (i) determine the diversity and abundance of Gracilaria in cage culture of Lawas, Sarawak (ii) assess the water quality of the cage culture area where Gracilaria is found and (iii) determine other aquatic organisms that found within Gracilaria population. Three field samplings had been conducted from October 2013 to November 2014 at cage culture areas of Awat-Awat Village, Lawas, Sarawak. Only single species of Gracilaria was found namely Gracilaria arcuata. Besides G. arcuata, Acanthophora sp. and Padina sp. were also found but in small patches. In addition, five different groups of aquatic invertebrates were observed namely tunicates, bivalves, polychaetes, small crabs and brittle stars. The selected water quality parameters namely temperature, pH, dissolved oxygen, salinity, turbidity, total suspended solid, orthophosphate, silicate and chlorophyll a were significantly different (p= 0.000) during all the three field samplings except for nitrite (p= 0.588). However, the values recorded were within normal range of standard water quality for tropical estuarine area. Since healthy population of Gracilaria could be easily found here, therefore this area has the potential for future seaweed aquacultur

Spatio-temporal patterns of land use/land cover change in the heterogeneous coastal region of Bangladesh between 1990 and 2017

Although a detailed analysis of land use and land cover (LULC) change is essential in providing a greater understanding of increased human-environment interactions across the coastal region of Bangladesh, substantial challenges still exist for accurately classifying coastal LULC. This is due to the existence of high-level landscape heterogeneity and unavailability of good quality remotely sensed data. This study, the first of a kind, implemented a unique methodological approach to this challenge. Using freely available Landsat imagery, eXtreme Gradient Boosting (XGBoost)-based informative feature selection and Random Forest classification is used to elucidate spatio-temporal patterns of LULC across coastal areas over a 28-year period (1990-2017). We show that the XGBoost feature selection approach effectively addresses the issue of high landscape heterogeneity and spectral complexities in the image data, successfully augmenting the RF model performance (providing a mean user's accuracy > 0.82). Multi-temporal LULC maps reveal that Bangladesh's coastal areas experienced a net increase in agricultural land (5.44%), built-up (4.91%) and river (4.52%) areas over the past 28 years. While vegetation cover experienced a net decrease (8.26%), an increasing vegetation trend was observed in the years since 2000, primarily due to the Bangladesh government's afforestation initiatives across the southern coastal belts. These findings provide a comprehensive picture of coastal LULC patterns, which will be useful for policy makers and resource managers to incorporate into coastal land use and environmental management practices. This work also provides useful methodological insights for future research to effectively address the spatial and spectral complexities of remotely sensed data used in classifying the LULC of a heterogeneous landscape

Mechanistic insights into MARK4 inhibition by galantamine toward therapeutic targeting of Alzheimer’s disease

Introduction: Hyperphosphorylation of tau is an important event in Alzheimer’s disease (AD) pathogenesis, leading to the generation of “neurofibrillary tangles,” a histopathological hallmark associated with the onset of AD and related tauopathies. Microtubule-affinity regulating kinase 4 (MARK4) is an evolutionarily conserved Ser-Thr (S/T) kinase that phosphorylates tau and microtubule-associated proteins, thus playing a critical role in AD pathology. The uncontrolled neuronal migration is attributed to overexpressed MARK4, leading to disruption in microtubule dynamics. Inhibiting MARK4 is an attractive strategy in AD therapeutics.Methods: Molecular docking was performed to see the interactions between MARK4 and galantamine (GLT). Furthermore, 250 ns molecular dynamic studies were performed to investigate the stability and conformational dynamics of the MARK4–GLT complex. We performed fluorescence binding and isothermal titration calorimetry studies to measure the binding affinity between GLT and MARK4. Finally, an enzyme inhibition assay was performed to measure the MARK4 activity in the presence and absence of GLT.Results: We showed that GLT, an acetylcholinesterase inhibitor, binds to the active site cavity of MARK4 with an appreciable binding affinity. Molecular dynamic simulation for 250 ns demonstrated the stability and conformational dynamics of the MARK4–GLT complex. Fluorescence binding and isothermal titration calorimetry studies suggested a strong binding affinity. We further show that GLT inhibits the kinase activity of MARK4 significantly (IC50 = 5.87 µM).Conclusion: These results suggest that GLT is a potential inhibitor of MARK4 and could be a promising therapeutic target for AD. GLT’s inhibition of MARK4 provides newer insights into the mechanism of GLT’s action, which is already used to improve cognition in AD patients

Lightweight encryption technique to enhance medical image security on internet of medical things applications

The importance of image security in the field of medical imaging is challenging. Several research works have been conducted to secure medical healthcare images. Encryption, not risking loss of data, is the right solution for image confidentiality. Due to data size limitations, redundancy, and capacity, traditional encryption techniques cannot be applied directly to e-health data, especially when patient data are transferred over the open channels. Therefore, patients may lose the privacy of data contents since images are different from the text because of their two particular factors of loss of data and confidentiality. Researchers have identified such security threats and have proposed several image encryption techniques to mitigate the security problem. However, the study has found that the existing proposed techniques still face application-specific several security problems. Therefore, this paper presents an efficient, lightweight encryption algorithm to develop a secure image encryption technique for the healthcare industry. The proposed lightweight encryption technique employs two permutation techniques to secure medical images. The proposed technique is analyzed, evaluated, and then compared to conventionally encrypted ones in security and execution time. Numerous test images have been used to determine the performance of the proposed algorithm. Several experiments show that the proposed algorithm for image cryptosystems provides better efficiency than conventional techniques

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe